Methanol → HCID 67314150, compound

Participants

Reaction Steps

Palladium on activated carbon (10 mg) was added to a solution of 2-aminocarbonylamino-5-[2-[2-(N-benzyl-N-methylamino)ethyloxy]-5-chlorophenyl]pyrrole-3-carboxamide (Compound No. 8-21, 26 mg, 0.059 mmol) in the mixed solvent (methanol:N,N-dimethylformamide=10:1, 2.2 mL) and the mixture was stirred at room temperature for 2.5 hours under hydrogen gas atmosphere. After the reaction solution was filtered, the filtrate was concentrated in vacuo. The obtained solid was washed with a mixed solvent (6 mL), which consists of chloroform and diethyl ether (1:1), and dried under reduced pressure to give the target compound (23 mg) quantitatively as a colorless solid.

Provenance & Evidence