HCID 57659777, compound → HCID 57659771, compound

Participants

Reaction Steps

To a solution of (6) (0.663 g, 1.52 mmol) in EtOAc (5 ml) was added a small spatula tip of 10% Pd(C) and placed on Parr shaker under hydrogen at 45 PSI. The mixture was shaken under hydrogen overnight. After addition of more EtOAc the mixture was filtered through celite, and concentrated in vacuo to yield (2R,4R)-4-(tert-butyldimethylsilyloxy)-2-ethyl-1-(4-(trifluoromethyl)phenylsulfonyl)pyrrolidine (7) (0.575 g, 86%) as a white crystalline solid. MS m/z 438.1 (M+H); retention time=6.841 min, method [10].

Provenance & Evidence