Trifluoroacetic acid → HCID 57659786, compound

Participants

Reaction Steps

tert-Butyl (3-((4-fluorophenyl)(hydroxy)methyl)-1-(methoxymethyl)-1H-pyrazol-4-yl)methyl(4-(trifluoromethyl)phenylsulfonyl)carbamate (44) (434 mg, 0.757 mmol) was dissolved in CH2Cl2 (4 mL) and stirred at rt under nitrogen. Trifluoroacetic acid (4 mL) was added and the reaction stirred for 1 hr before concentration in vacuo. The resulting crude product was purified by column chromatography using EtOAc/hexane gradients to yield N-((3-((4-fluorophenyl)(hydroxy)methyl)-1-(methoxymethyl)-1H-pyrazol-4-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide (45) (120 mg, 35%) as a white solid.

Provenance & Evidence