HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-bromo-3-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Bromo-3-fluorobenzoic acid | HCID 2773341 | — |
| Product | Methyl 4-bromo-3-fluorobenzoate | HCID 21951878 | 100% |
Reaction Steps
To a solution of 4-bromo-3-fluoro-benzoic acid (5.0 g, 22.9 mmol) in MeOH (60 mL) was added thionyl chloride (10 mL), This mixture was heated for about 5 h at 80 degrees Celsius until the starting material had been consumed, and then evaporated in vacuo to give white solid product (5.3 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977372B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-0674728ad4d64c3ba53b74a45c9b1c34 |
| Source note | uspto-grants-2011_07 |