2-(Azetidin-1-ylcarbonyl)-5-bromopyridine → HCID 53629668, compound

HRID 1011774Notes

Reaction equation

HRID 1011774 reaction equation
[N:1]1([C:5]([C:7]2[CH:12]=[CH:11][C:10](Br)=[CH:9][N:8]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1.[OH:14][C:15]1[CH:16]=[C:17]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=1)[C:18]([O:20]C)=[O:19]>>[N:1]1([C:5]([C:7]2[N:8]=[CH:9][C:10]([O:14][C:15]3[CH:16]=[C:17]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=3)[C:18]([OH:20])=[O:19])=[CH:11][CH:12]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 536296172-(Azetidin-1-ylcarbonyl)-5-bromopyridineHCID 59127146methyl 3-hydroxy-5-[(1S)-2-methoxy-1-methylethoxy]benzoate

Product 1

HCID 53629668HCID 53629668, compound

Procedure

3-{[6-(Azetidin-1-ylcarbonyl)pyridin-3-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}benzoic acid was prepared in an analogous fashion from 2-(azetidin-1-ylcarbonyl)-5-bromopyridine and methyl 3-hydroxy-5-[(1S)-2-methoxy-(1-methylethyl)oxy]benzoate.

Sources & evidence

ORD record
ord-6a7509aee64a4a719ff00327020df282
Source dataset
uspto-grants-2011_07
Patent number
US07977328B2

Reaction notes

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