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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011832Generated: October 26, 2026

methyl 3-(benzyloxy)-5-[(1R)-2-methoxy-1-methylethoxy]benzoate → Methyl 3-hydroxy-5-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}benzoate

https://huagongshe.com/reaction/1011832

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl 3-(benzyloxy)-5-[(1R)-2-methoxy-1-methylethoxy]benzoateHCID 59127090—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
SolventTetrahydrofuranHCID 8028—
ProductMethyl 3-hydroxy-5-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}benzoateHCID 59127121—

Reaction Steps

A solution of methyl 3-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate in THF (5 mL) and ethanol (5 mL), containing 10% palladium on carbon, was stirred under an atmosphere of hydrogen for 16 hours. The palladium on carbon was removed by filtration and the filtrate evaporated under reduced pressure to give the desired material as a clear gum (723 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07977328B2
Source datasetuspto-grants-2011_07
ORD IDord-a5420e4eb0ef4d8ea3f6333456bedaaa
Source noteuspto-grants-2011_07