HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011855Generated: November 3, 2026
Sodium Hydroxide → 2H-Azepin-2-one, 3-aminohexahydro-
https://huagongshe.com/reaction/1011855
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | L-Lysine monohydrochloride | HCID 69568 | — |
| Solvent | 1-Hexanol | HCID 8103 | — |
| Product | 2H-Azepin-2-one, 3-aminohexahydro- | HCID 102463 | — |
Reaction Steps
30 mmols of L-lysine hydrochloride 1 is neutralized with 30 mmols of NaOH and then 120 ml of 1-hexanol is added. This mixture is heated to 157° C. and is refluxed for 8 hours. The yield of α-amino-ε-caprolactam 2 produced by this reaction is about 89%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977450B2 |
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| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-4c5bc0bd4bc548c6b35d49e853c1c81d |
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| Source note | uspto-grants-2011_07 |
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