HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011857Generated: November 4, 2026
Propylene Glycol → 2H-Azepin-2-one, 3-aminohexahydro-
https://huagongshe.com/reaction/1011857
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propylene Glycol | HCID 1030 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | L-Lysine monohydrochloride | HCID 69568 | — |
| Product | 2H-Azepin-2-one, 3-aminohexahydro- | HCID 102463 | — |
Reaction Steps
300 mmols of L-lysine hydrochloride 1 is neutralized with 300 mmols of NaOH and then 1.2 L of 1,2-propanediol is added. This mixture is heated to 187° C. and is refluxed for 2 hours after removing about the 10% of the solvent when the reaction is first brought to reflux. The yield of α-amino-ε-caprolactam 2 produced by this reaction is about 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977450B2 |
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| Source dataset | uspto-grants-2011_07 |
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| ORD ID | ord-dd88d04dc2f44bbc9f0144bce7774165 |
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| Source note | uspto-grants-2011_07 |
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