ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate → 3,5-Dimethyl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:12])=[N:8][NH:9][C:10]=1[CH3:11])=[O:5])[CH3:2].[F:13][C:14]([F:24])([F:23])[O:15][C:16]1[CH:17]=[C:18](I)[CH:19]=[CH:20][CH:21]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:12])=[N:8][N:9]([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][C:14]([F:13])([F:23])[F:24])[CH:17]=2)[C:10]=1[CH3:11])=[O:5])[CH3:2]Participants
3
Procedure
The title compound was prepared in analogy to intermediate 6A by reaction of 3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester (2 g, 12 mmol) with 3-trifluoromethoxyiodobenzene (6.7 g, 14 mmol) affording the desired product (2.9 g, 73%) as a colourless liquid. MS: 329.2 (MH1).
Sources & evidence
- ORD record
- ord-1cda797ed0d14e63b45a44549a401f10
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07977358B2
Reaction notes
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