Sodium Hydroxide → 5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid

HRID 1011875Notes

Reaction equation

HRID 1011875 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[C:9]([CH3:26])=[N:10][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[C:12]=1[CH:13]1[CH2:15][CH2:14]1)=[O:7])C>>[CH:13]1([C:12]2[N:11]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=3)[N:10]=[C:9]([CH3:26])[C:8]=2[C:6]([OH:7])=[O:5])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 67314772cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 673145935-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid

Procedure

The title compound was prepared by sodium hydroxide hydrolysis of the minor isomer-cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester from formation of intermediate 11. MS: 311.1 (MH+).

Sources & evidence

ORD record
ord-8ae77db574334828a0d70d4bb8b230fd
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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