Sodium Hydroxide → 5-Cyclopropyl-3-methyl-1-(3-trifluoromethoxyphenyl)-1H-pyrazole-4-carboxylic acid

HRID 1011877Notes

Reaction equation

HRID 1011877 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[C:9]([CH3:27])=[N:10][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:26])([F:25])[F:24])[CH:17]=2)[C:12]=1[CH:13]1[CH2:15][CH2:14]1)=[O:7])C>>[CH:13]1([C:12]2[N:11]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:24])([F:25])[F:26])[CH:17]=3)[N:10]=[C:9]([CH3:27])[C:8]=2[C:6]([OH:7])=[O:5])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 673145905-cyclopropyl-3-methyl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 673142475-Cyclopropyl-3-methyl-1-(3-trifluoromethoxyphenyl)-1H-pyrazole-4-carboxylic acid

Procedure

The title compound was prepared by sodium hydroxide hydrolysis of the minor isomer-5-cyclopropyl-3-methyl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester from formation of intermediate 6. MS: 327.1 (MH+).

Sources & evidence

ORD record
ord-5fdce8927da34cc98b1deb27578c1856
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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