1-Benzyl-3-pyrrolidinone → 1-Benzyl-3-methylpyrrolidin-3-OL

HRID 1011883Notes

Reaction equation

HRID 1011883 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10](=[O:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][Mg]Cl>>[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([CH3:14])([OH:13])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 698901-Benzyl-3-pyrrolidinoneHCID 178418332HCID 178418332, compound

Product 1

HCID 186296481-Benzyl-3-methylpyrrolidin-3-OL

Procedure

Benzyl-3-methyl-pyrrolidin-3-ol was prepared as described in Tett Lett 1996, 37, 8, 1297, by addition of 1-benzylpyrolidin-3-one to methyl magnesium chloride.

Sources & evidence

ORD record
ord-8b43aa4630ef4d6aba3a7e9a1309a654
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…