2-(1,4-Diazepan-1-yl)ethan-1-ol → HCID 57554999, compound

HRID 1011891Notes

Reaction equation

HRID 1011891 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([N:16]3[C:20]([CH2:21][O:22][CH3:23])=[C:19]([C:24](O)=[O:25])[C:18]([CH2:27][O:28][CH3:29])=[N:17]3)[CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[N:30]1([CH2:37][CH2:38][OH:39])[CH2:36][CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([N:16]3[C:20]([CH2:21][O:22][CH3:23])=[C:19]([C:24]([N:33]4[CH2:34][CH2:35][CH2:36][N:30]([CH2:37][CH2:38][OH:39])[CH2:31][CH2:32]4)=[O:25])[C:18]([CH2:27][O:28][CH3:29])=[N:17]3)[CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27365502-(1,4-Diazepan-1-yl)ethan-1-olHCID 67314229HCID 67314229, compound2×

Product 1

HCID 57554999HCID 57554999, compound

Procedure

In analogy to the procedure described for example 1, 1-{3-[(E)-2-(4-chloro-phenyl)-vinyl]-phenyl}-3,5-bis-methoxymethyl-1H-pyrazole-4-carboxylic acid (intermediate 3) and 2-[1,4]diazepan-1-yl-ethanol gave the title compound as brown oil. MS: 539.3 (MH+, 1 Cl).

Sources & evidence

ORD record
ord-5a289ca6d7cf4ba6956e94e55e65ed56
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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