反应详情

A suspension of 0.90 g (2.71 mmol) of 5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (6′A) in 8.50 ml of DMSO was treated at RT with 1.35 ml (5.42 mmol) of aqueous 1N NaOH. After 2 h, reaction was diluted with chilled water and extracted 1× with Et2O. The water phase was acidified with aqueous 10% KHSO4 and extracted with Et2O (2×). These organic phases were washed with aqueous 10% NaCl, dried (Na2SO4) and evaporated to give 0.84 g (97%) of the title compound as white powder. MS: 317.1 (M−H−).

1. customreaction
2. extractionextracted 1× with Et2O
3. extractionextracted with Et2O (2×)
4. washThese organic phases were washed with aqueous 10% NaCl
5. dry with materialdried (Na2SO4)
6. customevaporated