HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → [5-(3-Benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazol-3-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-(1,4-Diazepan-1-yl)ethan-1-ol | HCID 2736550 | — |
| Reactant | 5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid | HCID 67315184 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | [5-(3-Benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazol-3-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone | HCID 68725339 | 32% |
Reaction Steps
In analogy to the procedure described in Example 16D], 5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid (Example 12C]) and 2-(1,4-diazepan-1-yl)ethan-1-ol with DCC and catalytic amount of DMAP gave the title compound in 32% yield as white foam. MS: 445.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-a5031a9c2de64577bcca245aa3c0a05e |
| Source note | uspto-grants-2011_07 |