2-(1,4-Diazepan-1-yl)ethan-1-ol → HCID 67313589, compound

HRID 1011899Notes

Reaction equation

HRID 1011899 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([C:22]([OH:24])=O)[CH:17]=1.[N:25]1([CH2:32][CH2:33][OH:34])[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([C:22]([N:28]2[CH2:29][CH2:30][CH2:31][N:25]([CH2:32][CH2:33][OH:34])[CH2:26][CH2:27]2)=[O:24])[CH:17]=1

Participants

3

Reactant 2

HCID 27365502-(1,4-Diazepan-1-yl)ethan-1-olHCID 67314339HCID 67314339, compound

Product 1

HCID 67313589HCID 67313589, compoundYield 5%

Procedure

In analogy to the procedure described in Example 12D], 5-(3-benzofuran-2-yl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid and 2-(1,4-diazepan-1-yl)ethan-1-ol gave [5-(3-benzofuran-2-yl-phenyl)-1-methyl-1H-pyrazol-3-yl]-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone in 5% yield as light yellow oil. MS: 445.1 (MH+).

Sources & evidence

ORD record
ord-fd329b59ed3849408443207494430b98
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…