1-(2-Methoxyethyl)piperazine → [5-(3-Benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone

HRID 1011906Notes

Reaction equation

HRID 1011906 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([C:22]([OH:24])=O)[C:17]=1[CH3:25].[CH3:26][O:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([C:22]([N:33]2[CH2:34][CH2:35][N:30]([CH2:29][CH2:28][O:27][CH3:26])[CH2:31][CH2:32]2)=[O:24])[C:17]=1[CH3:25]

Participants

3

Reactant 2

HCID 27346381-(2-Methoxyethyl)piperazineHCID 673142975-(3-benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazole-3-carboxylic acid

Product 1

HCID 67315318[5-(3-Benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone

Procedure

In analogy to the procedure described in Example 18], 5-(3-benzofuran-2-yl-phenyl)-1,4-dimethyl-1H-pyrazole-3-carboxylic acid (Example 16C]) and 1-(2-methoxy-ethyl)-piperazine gave the title compound in quant. yield as light brown foam. MS: 459.3 (MH+).

Sources & evidence

ORD record
ord-2f77bc6727ad48f7bf012b2d710a0adc
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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