Benzo[b]furan-2-boronic acid → HCID 68745270, compound

HRID 1011908Notes

Reaction equation

HRID 1011908 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14]([N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]3)=[O:15])[C:9]=2[CH3:26])[CH:5]=[CH:6][CH:7]=1.[O:27]1[C:31](B(O)O)=[CH:30][C:29]2[CH:35]=[CH:36][CH:37]=[CH:38][C:28]1=2>>[O:27]1[C:28]2[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=2[CH:30]=[C:31]1[C:5]1[CH:6]=[CH:7][CH:2]=[CH:3][C:4]=1[C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C:14]([N:16]2[CH2:20][CH2:19][CH:18]([N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])[CH2:17]2)=[O:15])[C:9]=1[CH3:26]

Participants

3

Reactant 2

HCID 2776266Benzo[b]furan-2-boronic acidHCID 67315151[5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

Product 1

HCID 68745270HCID 68745270, compoundYield 39%

Procedure

In analogy to the procedure described in Example 14C], [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone and benzo[b]furan-2-boronic acid gave the title compound in 39% yield as light brown foam. MS: 457.3 (MH+).

Sources & evidence

ORD record
ord-04b9f99e90724617b5da7b81dd0e5bf3
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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