HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-Dichlorobenzeneboronic acid → [5-(3',4'-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| Edukt | [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67315151 | — |
| Produkt | [5-(3',4'-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 57554968 | 55% |
Reaktionsschritte
In analogy to the procedure described in example 14C], [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone and 3,4-dichlorophenylboronic acid gave [5-(3′,4′-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone in 55% yield as light brown foam. MS: 485.2 (MH+, 2 Cl).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07977358B2 |
| Quelldatensatz | uspto-grants-2011_07 |
| ORD ID | ord-d15b8aff07b74f91a3be06d4c810f089 |
| Quellennotiz | uspto-grants-2011_07 |