HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo[b]furan-2-boronic acid → [1-(3-Benzofuran-2-yl-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo[b]furan-2-boronic acid | HCID 2776266 | — |
| Reactant | [1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67313795 | — |
| Product | [1-(3-Benzofuran-2-yl-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67314630 | 68% |
Reaction Steps
In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone and benzo[b]furan-2-boronic acid gave the title compound in 68% yield as light brown foam. MS: 457.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-485608d19c7848f1abe7955b6df2068f |
| Source note | uspto-grants-2011_07 |