3-(Diethylamino)pyrrolidine → HCID 178463850, compound

HRID 1011921Notes

Reaction equation

HRID 1011921 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[C:10]([C:13]([OH:15])=O)[C:9]=2[CH3:16])[CH:5]=[CH:6][CH:7]=1.[CH2:17]([N:19]([CH2:25][CH3:26])[CH:20]1[CH2:24][CH2:23][NH:22][CH2:21]1)[CH3:18]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[C:10]([C:13]([N:22]3[CH2:23][CH2:24][CH:20]([N:19]([CH2:25][CH3:26])[CH2:17][CH3:18])[CH2:21]3)=[O:15])[C:9]=2[CH3:16])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 199619953-(Diethylamino)pyrrolidineHCID 178429619HCID 178429619, compound

Product 1

HCID 178463850HCID 178463850, compoundYield 91%

Procedure

In analogy to the procedure described in example 12D], 5-(3-bromo-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid and 3-(diethylamino)pyrrolidine gave the title compound in 91% yield as off-white foam. MS: 405.2 (MH+, 1 Br).

Sources & evidence

ORD record
ord-cc1335ba36424d409af8dc20fb3dba41
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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