2-Chloro-1-fluoro-4-iodobenzene → HCID 178463855, compound

HRID 1011928Notes

Reaction equation

HRID 1011928 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](I)[CH:5]=[CH:4][C:3]=1[F:9].[CH2:10]([N:12]([CH2:34][CH3:35])[CH:13]1[CH2:17][CH2:16][N:15]([C:18]([C:20]2[C:24]([CH3:25])=[C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[CH:33])[CH:27]=3)[NH:22][N:21]=2)=[O:19])[CH2:14]1)[CH3:11]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:33]#[C:32][C:28]2[CH:27]=[C:26]([C:23]3[NH:22][N:21]=[C:20]([C:18]([N:15]4[CH2:16][CH2:17][CH:13]([N:12]([CH2:34][CH3:35])[CH2:10][CH3:11])[CH2:14]4)=[O:19])[C:24]=3[CH3:25])[CH:31]=[CH:30][CH:29]=2)[CH:5]=[CH:4][C:3]=1[F:9]

Participants

3

Reactant 2

HCID 27246052-Chloro-1-fluoro-4-iodobenzeneHCID 178436202(3-Diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone

Product 1

HCID 178463855HCID 178463855, compoundYield 68%

Procedure

In analogy to the procedure described in Example 31F], 2-chloro-1-fluoro-4-iodobenzene and (3-diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone (Example 31E]) gave the title compound in 68% yield light yellow foam. MS: 479.2 (MH+, 1 Cl).

Sources & evidence

ORD record
ord-b9bcf6d91ed04bdda4d2feff2d30247c
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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