HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbut-1-yne → (3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-but-1-ynyl)-phenyl]-1H-pyrazol-4-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbut-1-yne | HCID 69019 | — |
| Reactant | [1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67313795 | — |
| Product | (3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-but-1-ynyl)-phenyl]-1H-pyrazol-4-yl}-methanone | HCID 57554954 | — |
Reaction Steps
In analogy to the procedure described in Example 31F], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (1 eq) (Example 28A]) and 3-methyl-1-butyne (1.2 eq) gave the title compound in 90% yield yellow viscous oil. MS: 407.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-c5fea1a0733b40ffb83dfb41e02054e9 |
| Source note | uspto-grants-2011_07 |