4-(1-Pyrrolidinyl)piperidine → HCID 67315783, compound

HRID 1011932Notes

Reaction equation

HRID 1011932 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([OH:9])=O)=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)[N:3]=1.[N:20]1([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:1][C:2]1[C:6]([C:7]([N:28]2[CH2:29][CH2:30][CH:25]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:26][CH2:27]2)=[O:9])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)[N:3]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 22014745HCID 22014745, compound

Product 1

HCID 67315783HCID 67315783, compoundYield 93%

Procedure

In analogy to the procedure described in Example 18], 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the tide compound in 93% yield as green foam. MS: 398.1 (MH+).

Workup

  1. customgave the tide compound in 93% yield as green foam

Sources & evidence

ORD record
ord-e96d6b8c3693430583969e8cd2e3c7aa
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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