4-Chlorobenzoyl chloride → HCID 57554923, compound

HRID 1011935Notes

Reaction equation

HRID 1011935 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13]([CH3:14])=[C:12]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:19][CH2:18]3)=[O:16])[C:11]([CH3:28])=[N:10]2)[CH:6]=[CH:7][CH:8]=1.[Cl:29][C:30]1[CH:38]=[CH:37][C:33]([C:34](Cl)=[O:35])=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:38]=[CH:37][C:33]([C:34]([NH:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([N:9]3[C:13]([CH3:14])=[C:12]([C:15]([N:17]4[CH2:22][CH2:21][CH:20]([N:23]5[CH2:24][CH2:25][CH2:26][CH2:27]5)[CH2:19][CH2:18]4)=[O:16])[C:11]([CH3:28])=[N:10]3)[CH:4]=2)=[O:35])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 67315202HCID 67315202, compound

Product 1

HCID 57554923HCID 57554923, compoundYield 62%

Procedure

In analogy to the procedure described in Example 38E], [1-(3-amino-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone hydrochloride (Example 38D]) and 4-chlorobenzoyl chloride gave the title compound in 62% yield as yellow oil. MS: 506.3 (MH+, 1 Cl).

Sources & evidence

ORD record
ord-b0994c4c4be9433d954e20a87fe81781
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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