Dichloromethane → HCID 67314991, compound

HRID 1011938Notes

Reaction equation

HRID 1011938 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[NH:13][NH2:14].[CH3:15][CH2:16][O:17][C:18]([CH:20]([C:24]([CH3:26])=O)[C:21]([CH3:23])=O)=[O:19].C(Cl)Cl>C(Cl)Cl.CO>[CH2:16]([O:17][C:18]([C:20]1[C:21]([CH3:23])=[N:14][N:13]([C:4]2[CH:5]=[C:6]([C:9]([F:11])([F:12])[F:10])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[C:24]=1[CH3:26])=[O:19])[CH3:15]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 79063Ethyl 2-acetylacetoacetateHCID 22997635[2-Methoxy-5-(trifluoromethyl)phenyl]hydrazine

Product 1

HCID 67314991HCID 67314991, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

In analogy to the procedure described in Example 38A], (2-methoxy-5-trifluoromethyl-phenyl)-hydrazine and ethyl diacetoacetate gave, after flash column chromatography (CH2Cl2 to CH2Cl2:MeOH 99:1), the title compound in 58% yield as a light green solid. MS: 343.1 (MH+).

Workup

  1. customgave

Sources & evidence

ORD record
ord-5aefcf434cf5496e90537c6236f01375
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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