4-(1-Pyrrolidinyl)piperidine → HCID 57554986, compound

HRID 1011941Notes

Reaction equation

HRID 1011941 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[C:10]([CH3:17])=[N:9]2)[CH:7]=1.[N:20]1([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([N:28]3[CH2:29][CH2:30][CH:25]([N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[CH2:26][CH2:27]3)=[O:16])[C:10]([CH3:17])=[N:9]2)[CH:7]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 39380702HCID 39380702, compound

Product 1

HCID 57554986HCID 57554986, compoundYield 99%

Procedure

In analogy to the procedure described in Example 18], 1-(5-chloro-2-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 99% yield as light yellow foam. MS: 417.0 (MH+, 1 Cl).

Sources & evidence

ORD record
ord-e5d434be23a04c4c9c6437e36beb5c49
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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