Ethyl 2-acetylacetoacetate → ethyl 3,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate

HRID 1011942노트

반응식

HRID 1011942 반응식
Cl.[F:2][C:3]([F:14])([F:13])[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1.[CH3:15][CH2:16][O:17][C:18]([CH:20]([C:24]([CH3:26])=O)[C:21]([CH3:23])=O)=[O:19]>>[CH2:16]([O:17][C:18]([C:20]1[C:21]([CH3:23])=[N:12][N:11]([C:8]2[CH:7]=[CH:6][C:5]([O:4][C:3]([F:13])([F:14])[F:2])=[CH:10][CH:9]=2)[C:24]=1[CH3:26])=[O:19])[CH3:15]

참가 물질

3

반응물 2

HCID 79063Ethyl 2-acetylacetoacetateHCID 27773284-(Trifluoromethoxy)phenylhydrazine hydrochloride

생성물 1

HCID 23646848ethyl 3,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate수율 72%

실험 절차

In analogy to the procedure described in Example 38A], (4-trifluoromethoxy-phenyl)-hydrazine hydrochloride and ethyl diacetoacetate gave, after extraction (3× Et2O), drying (Na2SO4) and evaporation, the title compound in 72% yield as orange oil. MS: 328.9 (MH+).

후처리

  1. customgave
  2. extractionafter extraction (3× Et2O)
  3. customdrying
  4. custom(Na2SO4) and evaporation

출처 및 근거

ORD 기록
ord-ba75282944304bf294184a7360c7e186
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977358B2

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