4-(1-Pyrrolidinyl)piperidine → HCID 57555058, compound

HRID 1011943Notes

Reaction equation

HRID 1011943 reaction equation
[CH3:1][C:2]1[C:6]([C:7](O)=[O:8])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[N:3]=1.[N:22]1([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[C:6]([C:7]([N:30]2[CH2:31][CH2:32][CH:27]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:28][CH2:29]2)=[O:8])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=2)[N:3]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 66489331HCID 66489331, compound

Product 1

HCID 57555058HCID 57555058, compoundYield 95%

Procedure

In analogy to the procedure described in Example 18], 3,5-dimethyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 95% yield as light brown solid. MS: 437.2 (MH+).

Sources & evidence

ORD record
ord-075a053b7a8449a2943463fde5e31f28
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…