4-(1-Pyrrolidinyl)piperidine → HCID 57555099, compound

HRID 1011945Notes

Reaction equation

HRID 1011945 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([CH3:14])=[C:12]([C:15]([OH:17])=O)[C:11]([CH3:18])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:19]1([CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([CH3:14])=[C:12]([C:15]([N:27]3[CH2:28][CH2:29][CH:24]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[CH2:25][CH2:26]3)=[O:17])[C:11]([CH3:18])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 14913841-(3,4-dichlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 57555099HCID 57555099, compoundYield 87%

Procedure

In analogy to the procedure described in Example 181, 1-(3,4-Dichloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 87% yield as white foam. MS: 421.2 (MH+, 2 Cl).

Sources & evidence

ORD record
ord-37adcfb0c6d8404595fe341f4fe88768
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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