HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chlorophenylhydrazine hydrochloride → 1-(3-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| Reactant | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Product | 1-(3-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9965472 | 58% |
Reaction Steps
In analogy to the procedure described in Example 38A], 3-chlorophenylhydrazine hydrochloride and ethyl diacetoacetate gave the title compound after purification by flash column chromatography (n-heptane:EtOAc 9:1-1:1) in 58% yield as light yellow solid. MS: 279.0 (MH+, 1 Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-59f743d999b741b3a2f97438755cde7a |
| Source note | uspto-grants-2011_07 |