4-(1-Pyrrolidinyl)piperidine → HCID 57555014, compound

HRID 1011947Notes

Reaction equation

HRID 1011947 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[C:10]([CH3:17])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[N:18]1([CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH2:22][CH2:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([N:26]3[CH2:27][CH2:28][CH:23]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH2:24][CH2:25]3)=[O:16])[C:10]([CH3:17])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 8077307HCID 8077307, compound

Product 1

HCID 57555014HCID 57555014, compoundYield 98%

Procedure

In analogy to the procedure described in Example 18], 1-(3-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 98% yield as light brown solid. MS: 387.3 (MH+, Cl).

Sources & evidence

ORD record
ord-6c38eb0fe7a64abcbb35cb0348b3fe85
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…