4-(1-Pyrrolidinyl)piperidine → HCID 57554970, compound

HRID 1011949Notes

Reaction equation

HRID 1011949 reaction equation
[CH3:1][C:2]1[C:6]([C:7](O)=[O:8])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[N:3]=1.[N:22]1([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[C:6]([C:7]([N:30]2[CH2:31][CH2:32][CH:27]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:28][CH2:29]2)=[O:8])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]([F:19])([F:20])[F:21])[CH:12]=2)[N:3]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67315696HCID 67315696, compound

Product 1

HCID 57554970HCID 57554970, compoundYield 77%

Procedure

In analogy to the procedure described in Example 18], 3,5-dimethyl-1-(4-methyl-3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 77% yield as orange foam. MS: 435.5 (MH+).

Sources & evidence

ORD record
ord-1ae854faf0814591903055198676a3f4
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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