HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-(Trifluoromethyl)phenyl)hydrazine → 3-Methoxymethyl-5-methyl-1-(3-trifluoromethyl-phenyl)-1h-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-(Trifluoromethyl)phenyl)hydrazine | HCID 98650 | — |
| Reactant | Rac-2-acetyl-4-methoxy-3-oxo-butyric acid ethyl ester | HCID 87352689 | — |
| Product | 3-Methoxymethyl-5-methyl-1-(3-trifluoromethyl-phenyl)-1h-pyrazole-4-carboxylic acid ethyl ester | HCID 67313778 | 25% |
Reaction Steps
In analogy to the procedure described in Example 38A], 3-(trifluoromethyl)phenylhydrazine and rac-2-acetyl-4-methoxy-3-oxo-butyric acid ethyl ester gave after purification by flash column chromatography (CH2Cl2 to 5% Et2O/CH2Cl2) 5-methoxymethyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester and in 25% yield as light brown solid. MS: 343.0 (MH+) and 3-methoxymethyl-5-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester and in 36% yield as orange oil. MS: 343.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-855a37bc5e70499c8a34f103fe4a586c |
| Source note | uspto-grants-2011_07 |