4-(1-Pyrrolidinyl)piperidine → HCID 57555026, compound

HRID 1011952Notes

Reaction equation

HRID 1011952 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9](O)=[O:10])=[C:7]([CH3:12])[N:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[N:5]=1.[N:23]1([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9]([N:31]2[CH2:32][CH2:33][CH:28]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:29][CH2:30]2)=[O:10])=[C:7]([CH3:12])[N:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:21])([F:20])[F:22])[CH:14]=2)[N:5]=1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67314608HCID 67314608, compound

Product 1

HCID 57555026HCID 57555026, compoundYield 94%

Procedure

In analogy to the procedure described in Example 18], 3-methoxymethyl-5-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 94% yield as light yellow viscous oil. MS: 451.2 (MH+).

Sources & evidence

ORD record
ord-bdcc446a040a4042a5d23596ed800609
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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