4-(1-Pyrrolidinyl)piperidine → HCID 67314283, compound

HRID 1011954Notes

Reaction equation

HRID 1011954 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[N:7]=[C:6]([CH3:19])[C:5]=1[C:20]([OH:22])=O.[N:23]1([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][CH2:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:16])[F:17])[CH:10]=2)[N:7]=[C:6]([CH3:19])[C:5]=1[C:20]([N:31]1[CH2:32][CH2:33][CH:28]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:29][CH2:30]1)=[O:22]

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67314218HCID 67314218, compound

Product 1

HCID 67314283HCID 67314283, compoundYield 95%

Procedure

In analogy to the procedure described in Example 18], 5-methoxymethyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave the title compound in 95% yield as light brown viscous oil. MS: 451.2 (MH+).

Sources & evidence

ORD record
ord-aa464ccfced94949b8914bc1c48d3d49
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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