4-(1-Pyrrolidinyl)piperidine → HCID 57554978, compound

HRID 1011957Notes

Reaction equation

HRID 1011957 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)=[C:5]([CH3:17])[C:4]([C:18]([OH:20])=O)=[N:3]1.[N:21]1([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH2:25][CH2:24][CH2:23][CH2:22]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:8]=2)=[C:5]([CH3:17])[C:4]([C:18]([N:29]2[CH2:30][CH2:31][CH:26]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)[CH2:27][CH2:28]2)=[O:20])=[N:3]1

Participants

4

Reactant 3

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 67314941HCID 67314941, compound

Product 1

HCID 57554978HCID 57554978, compound

Procedure

In analogy to the procedure described for Example 1, 1,4-dimethyl-5-(3-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid and 4-pyrrolidine-1-yl-piperidine with HATU/iPr2Net gave the title compound as yellow oil. MS: 421.1 (MH+).

Sources & evidence

ORD record
ord-500641d0968f43009376fe0caed88917
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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