HuagongsheHuagongshe Chemistry Print Report · For research reference only
((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride → [4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-methyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride | HCID 66901571 | — |
| Reactant | 5-Methyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid | HCID 67315190 | — |
| Product | [4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-[5-methyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-methanone | HCID 57554953 | 78% |
Reaction Steps
In analogy to the procedure described in Example 160E], 5-methyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid (Example 160D]) and ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride gave the title compound in 78% yield as a light yellow foam. MS: 530.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-4b66a905311a485b971abe8bffd7c199 |
| Source note | uspto-grants-2011_07 |