Water → 5-Cyclopropyl-3-pyridin-4-yl-1H-pyrazole-4-carboxylic acid ethyl ester

Participants

Reaction Steps

220 mg (0.84 mmol) of 3-cyclopropyl-3-oxo-2-(pyridine-4-carbonyl)-propionic acid ethyl ester and 57 mg (0.84 mmol) hydrazine.hydrochloride were dissolved in 3 ml ethanol, 1.5 ml water and 0.2 ml 4M HCl dioxane. The yellow solution was stirred 1 h at room temperature. The reaction mixture was evaporated, the residue taken in EtOAc and washed with brine, the aqueous layers were extracted with EtOAc. The combined organic phases were dried over magnesium sulfate and evaporated. The title compound was received as yellow gum (148 mg, 68%). MS: 258.0 (MH+).

Provenance & Evidence