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((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride → [5-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride | HCID 66901571 | — |
| 反応物 | 5-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid | HCID 67315604 | — |
| 生成物 | [5-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone | HCID 25206418 | 56% |
反応手順
In analogy to the procedure described in Example 160E, 5-cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid (Example 162D]) and ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride (Example 161A]) gave the title compound as a light brown oil (56%). MS: 556.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07977358B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-ab2c0625db9940849502e836c9e675f1 |
| 出典メモ | uspto-grants-2011_07 |