4-(1-Pyrrolidinyl)piperidine → HCID 25206419, compound

HRID 1011972Notes

Reaction equation

HRID 1011972 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[C:5]=2[C:25]([OH:27])=O)[CH2:3][CH2:2]1.[N:28]1([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[C:5]=2[C:25]([N:36]2[CH2:37][CH2:38][CH:33]([N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[CH2:34][CH2:35]2)=[O:27])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67314108HCID 67314108, compound

Product 1

HCID 25206419HCID 25206419, compoundYield 70%

Procedure

In analogy to the procedure described in Example 160E], 5-cyclopropyl-3-pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid and 4-(1-pyrrolidinyl)piperidine gave the title compound as a light yellow solid (70%). MS: 510.4 (MH+).

Sources & evidence

ORD record
ord-b577486cc15f4cb8a59b16d85dcee172
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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