4-Pyridinecarboxaldehyde → HCID 87352693, compound

Participants

Reaction Steps

3-(Trifluoromethyl)phenylhydrazine (176 mg, 1 mmol) in 5 ml of acetic acid were treated with sodium acetate (164 mg, 2 mmol) and pyridine-4-carbaldehyde (0.11 ml, 1 mmol) during 1 h at 50° C. The yellow solution was cooled and ammonium hydroxide 25% was added, the solid was collected, washed with water and recrystallized from EtOAc:n-heptane. The title compound was obtained as a yellow solid (195 mg, 74%). MS: 266.1 (MH+).

Provenance & Evidence