4-(1-Pyrrolidinyl)piperidine → HCID 57555084, compound

HRID 1011981Notes

Reaction equation

HRID 1011981 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[C:3]=1[C:21](O)=[O:22].[N:24]1([CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:14])[F:15])[CH:8]=2)[N:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[C:3]=1[C:21]([N:32]1[CH2:33][CH2:34][CH:29]([N:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:30][CH2:31]1)=[O:22]

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 86626594HCID 86626594, compound

Product 1

HCID 57555084HCID 57555084, compoundYield 88%

Procedure

In analogy to the procedure described in Example 160E), 5-methyl-3-trifluoromethyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid and 4-(1-pyrrolidinyl)piperidine gave the title compound as a yellow foam (88%). MS: 475.2 (MH+).

Sources & evidence

ORD record
ord-8fe350c376a34aa894841190602eec2b
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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