Hydrazinium chloride → HCID 178469165, compound

HRID 1011983Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:25])[CH:5]([C:20]([CH:22]1[CH2:24][CH2:23]1)=O)[C:6](=O)[CH2:7][N:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[CH3:2].Cl.[NH2:27][NH2:28]>>[CH2:1]([O:3][C:4]([C:5]1[C:6]([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=[N:27][NH:28][C:20]=1[CH:22]1[CH2:24][CH2:23]1)=[O:25])[CH3:2]

Participants

Reactant 2

HCID 115031Hydrazinium chloride

HCID 67314385HCID 67314385, compound

Product 1

HCID 178469165HCID 178469165, compoundYield 36%

Procedure

In analogy to the procedure described in Example 160B]), 2-cyclopropanecarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyric acid ethyl ester and hydrazine.hydrochloride gave the title compound as a light yellow solid (36%). MS: 338.5 (M−H−).

Sources & evidence

ORD record: ord-f69cb96e2a3e4a3f855e1e1bd99a7468
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07977358B2

Reaction notes

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