4-(1-Pyrrolidinyl)piperidine → HCID 57554942, compound

HRID 1011988Notes

Reaction equation

HRID 1011988 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=2)[N:5]=[C:4]([C:18]2[CH:19]=[N:20][CH:21]=[N:22][CH:23]=2)[C:3]=1[C:24]([OH:26])=O.[N:27]1([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=2)[N:5]=[C:4]([C:18]2[CH:19]=[N:20][CH:21]=[N:22][CH:23]=2)[C:3]=1[C:24]([N:35]1[CH2:36][CH2:37][CH:32]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:33][CH2:34]1)=[O:26]

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67315302HCID 67315302, compound

Product 1

HCID 57554942HCID 57554942, compoundYield 32%

Procedure

In analogy to the procedure described in Example 160E], 5-methyl-3-pyrimidin-5-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and 4-(1-pyrrolidinyl)piperidine gave the title compound as a yellow oil (32%). MS: 501.0 (MH+).

Sources & evidence

ORD record
ord-9b87029207a84c79bf9701a02d501df2
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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