HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-cyclopropyl-3-oxopropanoate → 2-Cyclopropanecarbonyl-3-oxo-3-pyrimidin-5-yl-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-cyclopropyl-3-oxopropanoate | HCID 262979 | — |
| Reactant | Pyrimidine-5-carbonyl chloride | HCID 15839553 | — |
| Product | 2-Cyclopropanecarbonyl-3-oxo-3-pyrimidin-5-yl-propionic acid ethyl ester | HCID 67314376 | 40% |
Reaction Steps
In analogy to the procedure described in Example 162A], 3-cyclopropyl-3-oxo-propionic acid ethyl ester and pyrimidine-5-carbonyl chloride gave the title compound as a yellow oil (40%). MS: 261.3 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-3d9bef452497492ca73ccdc5cee595de |
| Source note | uspto-grants-2011_07 |