HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazinium chloride → 5-cyclopropyl-3-pyrimidin-5-yl-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazinium chloride | HCID 115031 | — |
| Reactant | 2-Cyclopropanecarbonyl-3-oxo-3-pyrimidin-5-yl-propionic acid ethyl ester | HCID 67314376 | — |
| Product | 5-cyclopropyl-3-pyrimidin-5-yl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 67313825 | 39% |
Reaction Steps
In analogy to the procedure described in Example 162B], 2-cyclopropanecarbonyl-3-oxo-3-pyrimidin-5-yl-propionic acid ethyl ester and hydrazine.hydrochloride gave the title compound as white solid (39%). MS: 259.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-ed9e3b65eb7543a28052ccc672f76804 |
| Source note | uspto-grants-2011_07 |