HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)phenylboronic acid → 5-Cyclopropyl-3-pyrimidin-5-yl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)phenylboronic acid | HCID 2734386 | — |
| Reactant | 5-cyclopropyl-3-pyrimidin-5-yl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 67313825 | — |
| Product | 5-Cyclopropyl-3-pyrimidin-5-yl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 67313684 | 29% |
Reaction Steps
In analogy to the procedure described in Example 162C], 5-cyclopropyl-3-pyrimidin-5-yl-1H-pyrazole-4-carboxylic acid ethyl ester (Example 177B]) and 4-(trifluoromethoxy)benzeneboronic acid gave the title compound as a yellow oil (29%). MS: 419.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-be8ca5f86bfa471b897c88bb898abc86 |
| Source note | uspto-grants-2011_07 |