(R)-3-Pyrrolidinol → HCID 57555052, compound

HRID 1012003Notes

Reaction equation

HRID 1012003 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1.[OH:29][C@@H:30]1[CH2:34][CH2:33][NH:32][CH2:31]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:23][CH2:24][CH:25]([N:32]3[CH2:33][CH2:34][C@@H:30]([OH:29])[CH2:31]3)[CH2:26][CH2:27]2)=[O:21])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 67314190[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one

Product 1

HCID 57555052HCID 57555052, compound

Procedure

The title compound was prepared from 1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one (Example 181B) and (R)-3-hydroxyl-pyrrolidine in direct analogy to the general procedure used in example 129. MS: 463.3 (MH+).

Sources & evidence

ORD record
ord-03a401439c5e454a9c99d6e669303669
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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