HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid → [5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-((trans)-2-hydroxymethyl-4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid | HCID 67314593 | — |
| Reactant | trans-(4-Pyrrolidin-1-yl-piperidin-2-yl)-methanol dihydrochloride | HCID 67315091 | — |
| Product | [5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-((trans)-2-hydroxymethyl-4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 67314130 | — |
Reaction Steps
The title compound was prepared from 5-cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid (Example 181A) and trans-(4-pyrrolidin-1-yl-piperidin-2-yl)-methanol dihydrochloride (example 193B) in direct analogy to the general procedure used in example 150. MS: 477.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-ea7b9da7aaa34fcc8cd8c4fc437212c3 |
| Source note | uspto-grants-2011_07 |